Once weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double blind, placebo controlled and active controlled, dose finding phase 2 trial The Lancet Here's the basic distinction: Weight loss = reduction in total body weight. The scale goes down, but that loss can come from any combination of fat, water, and lean mass (muscle, Sermorelin 2mg Tesamorelin 13mg + Ipamorelin 3mg (16mg Peptide Blend)